ABCD2 Antibody

Western Blot: ABCD2 Antibody [NBP2-26123] - NBP2-26123 (1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

ABCD2 Antibody Summary

• Description: Novus Biologicals Goat ABCD2 Antibody (NBP2-26123) is a polyclonal antibody validated for use in WB and ELISA. Anti-ABCD2 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-PLSDTLAIKGKVID corresponding to internal region according to NP_005155.1.
• Specificity: No cross-reactivity expected with ABCD1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ABCD2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 0.5 - 2 ug/ml
• Application Notes: WB: Approx. 80 kDa band observed in human liver lysates (calculated MW of 83.2 kDa band according to NP_005155.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ABCD2 Antibody

• Adrenoleukodystrophy-like 1
• Adrenoleukodystrophy-related protein
• ALD1
• ALDL1ATP-binding cassette sub-family D member 2
• ALDRhALDR
• ALDRPABC39
• ATP-binding cassette, sub-family D (ALD), member 2

Background

The protein encoded by the ABCD2 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into sevendistinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily,which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomalABC transporters are half transporters which require a partner half transporter molecule to form a functionalhomodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however thisprotein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters.Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. Thisgene has been identified as a candidate for a modifier gene, accounting for the extreme variation amongadrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, agenetically heterogeneous disorder of peroxisomal biogenesis. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCD2 Antibody (NBP2-26123)(1)

Publication using NBP2-26123

• van Roermund CW, Visser WF, Ijlst L et al. Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid beta-oxidation. Biochim Biophys Acta 2011-03-01 [PMID: 21145416]

Bioinformatics

• Gene Symbol: ABCD2
• Entrez:
  • 225(Human)