A2BP1 Antibody (D8H8) [Allophycocyanin]

• Reactivity: Hu, Mu
• Applications: WB, ICC/IF, IHC, IP
• Clone: D8H8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

A2BP1 Antibody (D8H8) [Allophycocyanin] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Mouse recombinant A2BP1 [Swiss-Prot# Q9JJ43]
• Localization: Nucleus. Cytoplasm. Note: Predominantly nuclear.
• Specificity: Does not cross react with paralogue FOX2
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: RBFOX1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: This A2BP1 Antibody (D8H8) is useful for Immunocytochemistry/Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry on paraffin embedded sections. In Western Blot, a band is seen 50-55 kDa representing A2BP1. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
  
  Recommended applications are based on validated applications from the unconjugated base product NBP2-13169. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for A2BP1 Antibody (D8H8) [Allophycocyanin]

• 2BP1
• A2BP
• A2BP1 Hexaribonucleotide-binding protein 1
• Ataxin-2-binding protein 1
• FOX1 hexaribonucleotide binding protein 1
• Fox-1 homolog A
• FOX-1
• HRNBP1 ataxin 2-binding protein 1
• RNA binding protein fox-1 homolog 1
• RNA binding protein, fox-1 homolog (C. elegans) 1

Background

Ataxin-2 binding protein 1 has an RNP motif that is highly conserved among RNA-binding proteins. This protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes familial neurodegenerative diseases. Ataxin-2 binding protein 1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been found but their full length nature has not been determined. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBFOX1