5-HT2A Antibody

Product Discontinued

5-HT2A Antibody Summary

• Immunogen: Peptide with sequence KNSKQDAKTTDNDCS corresponding to internal region according to NP_000612.1.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: HTR2A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 ug/mL
  • Peptide ELISA Detection limit 1:1000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for 5-HT2A Antibody

• 5-HT2 receptor
• 5-HT-2
• 5HT2A
• 5-HT2A
• 5-HT-2A
• 5-hydroxytryptamine (serotonin) receptor 2A
• 5-hydroxytryptamine receptor 2A
• HTR2,5-HT2A
• HTR2A
• serotonin 5-HT-2A receptor
• Serotonin receptor 2A

Background

The 5HT2A Receptor gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene areassociated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated withresponse to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also havea mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressantdownregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for 5-HT2A Antibody (NBP1-20933)(1)

Publication using NBP1-20933

• Zaniewska M, McCreary AC, Przegalinski E, Filip M. Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats. Eur J Pharmacol 2007-10-01 [PMID: 17617403]

Bioinformatics

• Gene Symbol: HTR2A
• Entrez:
  • 3356(Human)
• Uniprot:
  • NP_000612.1(Human)