14-3-3 zeta Antibody (818515) [HRP]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 818515
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: HRP

14-3-3 zeta Antibody (818515) [HRP] Summary

• Immunogen: E. coli-derived recombinant human 14-3-3 zeta
  Asp2-Asn245
  Accession # P63104
• Specificity: Detects human 14-3-3 zeta in direct ELISAs and Western blots. Detects Mouse and Rat 14-3-3 zeta in Western Blots. In direct ELISAs, no
  cross-reactivity with recombinant human 14-3-3 beta, theta, eta, gamma, sigma, or epsilon is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: YWHAZ
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for 14-3-3 zeta Antibody (818515) [HRP]

• 1433 zeta
• 14-3-3 zeta
• KCIP-1
• KCIP-1MGC126532,14-3-3-zeta
• MGC111427
• MGC138156
• tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, deltapolypeptide
• tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zetapolypeptide
• YWHAZ
• zeta polypeptide

Background

14-3-3 zeta is a protein that mediates signal transduction by binding to phosphoserine-containing proteins. The protein is widely expressed in various gray matter regions of the brain. Overexpression of the 14-3-3 zeta gene has been found to correlate with chemoresistance to anthracyclines and metastatis recurrence of human breast cancer. These effects are likely caused by an anti-apoptotic mechanism of 14-3-3 zeta during anthracycline treatment.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: YWHAZ