FoxP3 Products

Description

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Bioinformatics

Entrez	20371 Mouse 317382 Rat 50943 Human
Uniprot	NM_014009 Human NP_001107849.1 Human NP_054728 Human NP_054728.2 Human NP_054728.2 Human NP_473380.1 Mouse Q99JB6 Mouse Q9BZS1 Human
Product By Gene ID	50943
Alternate Names	AIID AIIDMGC141961 DIETER forkhead box P3 Forkhead Box Protein P3 FOXP3delta7 immune dysregulation, polyendocrinopathy, enteropathy, X-linked Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked IPEX JM2 MGC141961 MGC141963 PIDX PIDXMGC141963 scurfin SCURFIN Scurfin XPID XPIDpolyendocrinopathy, enteropathy, X-linked

Research Areas for FoxP3

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Biology
Chromatin Research
Immunology
Transcription Factors and Regulators

Related FoxP3 Blog Posts

Check out the latest blog posts on FoxP3.

FOXP3 Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function.  Distinctively, ...    Read more.

Meeting Report: 2nd International Antibody Validation Meeting Bio-Techne brands Novus Biologicals® and R&D Systems® were proud to support the 2nd International Antibody Validation Meeting held at Bath University, on the 15-16 September, 2016. Almost 100 participants from around the world, including funde...    Read more.

FOXP3: Master Regulatory Transcriptional Factor FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system hom...    Read more.

FOXP3 is a Master Regulator of T Regulatory (Treg) Cells FOXP3, a member of forkhead/winged-helix family of transcription factors acts as a "master" regulator for the development and suppressive function of regulatory T cells (Tregs). Its constitutive expression is necessary for the suppressive function of ...    Read more.

Read more FoxP3 related blogs.