cIAP-2/HIAP-1 Antibody (E40)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

cIAP-2, also known as HIAP-1, is a member of the inhibitor of apoptosis (IAP) family of proteins. These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus (1). cIAP-2 is localized to the cytoplasm. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). This complex is thought to play a role in inhibition of apoptosis (2,3). cIAP-2 inhibits cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade and apoptosis (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-57030	Applications	Species
Coordinated Ubiquitination and Phosphorylation of RIP1 Regulates Necroptotic Cell Death de Almagro MC, Goncharov T, Izrael-Tomasevic A et al. Cell Death Differ. [PMID: 27518435] (WB, Human)	WB	Human
Simon PS, Bardhan K, Chen MR et al. NF-kB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression. Oncotarget. 2016-04-26 [PMID: 27014915] (WB, Human)	WB	Human
Varfolomeev E, Goncharov T, Vucic D. Roles of c-IAP Proteins in TNF Receptor Family Activation of NF-kB Signaling Methods Mol. Biol. 2015-03-04 [PMID: 25736754] (WB, Human)	WB	Human
Loeder S, Zenz T, Schnaiter A et al. A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res 2009-12-01 [PMID: 19920200]
Hacker S, Dittrich A, Mohr A et al. Histone deacetylase inhibitors cooperate with IFN-? to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8 . Oncogene 28 3097-3110. 2009-01-01 [PMID: 19597472] (WB)	WB
Fakler M, Loeder S, Vogler M et al. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood. 2009-02-19 [PMID: 19036706] Details: WB (human leukemia cell lines), Fig. 1A.
Waldele K, Silbermann K, Schneider G et al. Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes . Blood 107 4491-4499. 2006-01-01 [PMID: 16467195] (WB)	WB

Array NB110-57030

• cIAP-2/HIAP-1 Antibodies
• cIAP-2/HIAP-1 Lysates
• cIAP-2/HIAP-1 Proteins
• cIAP-2/HIAP-1 Proteins and Enzyme