City Gym Helps Sheffield University in FTO Fat Gene Research

Mon, 04/19/2010 - 03:36

The recently discovered FTO (Fat mass and obesity orientated) gene is of great interest to antibody research groups, throwing clearer insight into the reasons why some people have difficulty losing weight, even when following a healthy lifestyle.

Studies into serotonin (5-HT) are equally important, and its importance has been realised in a number of antibody studies into causes of weight gain. 5-HT receptors are located in the hypothalamus, which is a primary expression site for FTO. A number of research groups are currently looking at the way these two proteins may interact.

Recently, more than 70 obese volunteers signed up to a Sheffield sports centre to take part in a genetic study being conducted by the city's Hallam University. The research, which started early in 2009 and is ongoing, looks at changes in participants' motivation, compared to the levels of serotonin that is naturally released.

In vitro FTO antibody studies, using sera taken from human volunteers, have previously shown that higher levels of physical activity blocks the effects of the FTO gene. At the University of Maryland in 2008, researchers analysed activity levels against gene variants in a number of exercisers. They found the least FTO activity in those who were physically most active.

Western Blot: FTO Antibody Western Blot: FTO Antibody

Serotonin, otherwise known as the 'happy hormone' has been shown to aid weight loss in a number of ways, including appetite suppression and motivation to energise. Therefore, it has an important role to play in blocking the release of FTO. We at Novus Biologicals have a wide range of FTO and serotonin antibodies on our antibody database, which will help to facilitate this research.

Novus Biologicals offers many FTO reagents for your research needs including:



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