Antibody suppliers

Florescence activated cell sorting or Flow cytometry permits concurrent measurements of numerous florescence and light scattered events by illuming single cells or molecules in suspension as they flow through a sensing area. Distinct cells or particles could be tangibly separated corresponding to their biochemical properties and biological parameters, while the light is scattered on the molecules either in the form of forward or side scatter.

Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus also playing a part in cellular immunity. For example, B cell depletion therapy, a new treatment for autoimmune disorders, has been found to influence T cells in addition to antibody titers.

Vascular endothelial growth factor receptors 1 and 2 (VEGFR1 and VEGFR2) are related family members of the vascular endothelial growth factor (VEGF) family of membrane receptor tyrosine kinases. They are key regulators of physiological angiogenesis during fundamental developmental processes such as embryogenesis, skeletal growth, and reproductive functions.

Studies on leukemias and other blood related malignancies is one of the most relevant investigational and medicinal applications of flow cytometry. In the bone marrow, normal blood cells undergo a progressive series of differentiation and branch off as myeloid, B and T cells. Hematological disorders can arise at any stage of the cell, while the differentiating cell will express a distinctive marker depending on the stage of differentiation.

Ku70, known by several synonyms including X-ray repair cross-complementing, 5'-deoxyribose-5-phosphate lyase Ku70 protein 6, 70 kDa subunit of Ku antigen, XRCC6, and G22P1, is a 70 kDa protein that was shown to be involved in multiple cellular pathways, mainly involving DNA repair and recombination (2).

Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved.

Protein tyrosine phosphorylation is a fundamental mechanism for controlling many aspects of cellular processes, as well as aspects of human health and diseases. Compared with phosphoserine and phosphothreonine, phosphotyrosine signaling is more tightly regulated, but often more challenging to characterize, due to significantly lower levels of tyrosine phosphorylation (1). While phosphorylation in general is fairly common, tyrosine phosphorylation is very rare.

Toll-like receptors (TLRs) play an essential role in the activation of innate immunity, and TLRs are expressed in a large number of immune cells as well as in epithelial cells. TLR9 recognizes synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytidyl-deoxyguanosine (CpG) motifs and mimics the immunostimulatory activity of bacterial DNA.

In the UK, 127,000 people are affected by the progressive neurodegenerative condition Parkinson's disease. Parkinson's is extremely difficult to diagnose in its early stages. The current method of diagnosis includes examination for physical signs of Parkinson's along with a detailed history of symptoms. The defining neuropathological characteristics of Parkinson's disease is Lewy bodies.

Over the years muscular dystrophies have become a popular area of research. These are a group of inherited disorders that involve an increase in muscle weakness over time. These disorders greatly decrease the quality of life and there are no known cures. Research in this area appears to have excelled in the past two years with findings related to the genes NCoR and EZH2.