TrkA Products

Description

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Bioinformatics

Entrez	18211 Mouse 4914 Human 59109 Rat
Uniprot	AAA36770 Human NM_001007792 Human NM_001012331 Human NM_002529 Human NP_001007793 Human NP_001012331 Human NP_002520 Human P04629 Human P35739 Rat
Product By Gene ID	4914
Alternate Names	DKFZp781I14186 EC 2.7.10 EC 2.7.10.1 MTChigh affinity nerve growth factor receptor Neurotrophic tyrosine kinase receptor type 1 neurotrophic tyrosine kinase, receptor, type 1 p140-TrkA TRK1-transforming tyrosine kinase protein Trk-A TRKAOncogene TRK TRKTRK1 tyrosine kinase receptor A

Research Areas for TrkA

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Immunology
Neuroscience
Phospho-Specific
Protein Kinase

Related TrkA Blog Posts

Check out the latest blog posts on TrkA.

TrkB: Docking for Neurotrophins and Beyond. Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.

TrkB: Bridging Ontogenesis and Oncogenesis Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...    Read more.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

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