TrkA Products

Description

Neurotrophins activate tyrosine kinase receptors of the trk family (trkA, trkB and trkC) and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not appear to directly transduce NGF signals, this receptor appears to increase the responsiveness of the trk receptors and plays a role in the retrograde transport of neurotrophin signals from axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is tabulated by Barbacid (1994). NGF binds with high affinity and activates the TrkA tyrosine kinase receptor, which is apparently responsible for signal transduction. BDNF activates the TrkB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine kinase receptor, but can also activate TrkA and TrkB receptors in certain cell systems. NT-4 primarily activates the TrkB tyrosine kinase receptor, which it shares with BDNF.

Bioinformatics

Entrez	4914 Human
Uniprot	P04629
Product By Gene ID	4914
Alternate Names	DKFZp781I14186 EC 2.7.10 EC 2.7.10.1 MTChigh affinity nerve growth factor receptor Neurotrophic tyrosine kinase receptor type 1 neurotrophic tyrosine kinase, receptor, type 1 NTRK1 NTRK-1 p140-TrkA TRK1-transforming tyrosine kinase protein TrkA Trk-A TRKAOncogene TRK TRKTRK1 tyrosine kinase receptor A

Research Areas for TrkA

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Immunology
Neuroscience

Related TrkA Blog Posts

Check out the latest blog posts on TrkA.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

TrkB: Bridging Ontogenesis and Oncogenesis Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...    Read more.

TrkB: Docking for Neurotrophins and Beyond. Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.

Read more TrkA related blogs.