TrkC Products

Description

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq]

Bioinformatics

Entrez	4916 Human
Uniprot	NP_001007157.1 Human
Product By Gene ID	4916
Alternate Names	EC 2.7.10 EC 2.7.10.1 ETS related protein-neurotrophic receptor tyrosine kinase fusion protein ETV6-NTRK3 fusion gp145(trkC) GP145-TrkC Neurotrophic tyrosine kinase receptor type 3 neurotrophic tyrosine kinase, receptor, type 3 NT 3 receptor NT-3 growth factor receptor NTRK3 TrkC tyrosine kinase TrkC trk-C TRKCneurotrophin 3 receptor tyrosine kinase receptor C

Research Areas for TrkC

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Kinase

Related TrkC Blog Posts

Check out the latest blog posts on TrkC.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

TrkB: Bridging Ontogenesis and Oncogenesis Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...    Read more.

TrkB: Docking for Neurotrophins and Beyond. Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.

Read more TrkC related blogs.