Antibody suppliers

Ubiquitin is an abundant and essential cellular 9-kd protein that is conserved across evolution from yeast to humans. Ubiquitin is used by cells as a covalent modifier of other proteins both to activate their function and to target them for degradation, depending on the degree of ubiquitination.

 Tyrosine hydroxylase catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. A hallmark of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra. Mutations in cases of autosomal recessive dopa-responsive dystonia and infantile Parkinsonism have also been identified recently.

Platelet endothelial cell adhesion molecule PECAM1 (also called CD31) is a 130 kDa type I transmembrane glycoprotein that is expressed on most cells of the hematopoietic lineage including platelets, monocytes, neutrophils and certain lymphocyte subsets (1). It has also been suggested that PECAM-1 contributes to endothelial cell barrier function.

Gap junctions consist of Connexins (Cx), a family of proteins that form channels linking the cytoplasm of adjacent cells. All Connexin molecules have four membrane-spanning domains, two extracellular domains, and a cytoplasmic carboxy-terminal tail of varying length that has an important role in the regulation of the gating properties of the channel. Interestingly Connexin 43 also known as gap junction alpha-1 protein is one of the most abundant gap-junction protein.

Nucleolin is a ubiquitous, nonhistone nucleolar phosphoprotein of exponentially growing eukaryotic cells and is present in abundance at the dense fibrillar and granular regions of nucleolus. Intact nucleolin is the major species and represents 5% of nucleolar protein in actively dividing cells.

Cells of the human body defend themselves against viral infection, but faults in this system could make some people susceptible to suffering particularly bad flu. IFITM3 (interferon-induced transmembrane protein 3) is an antiviral protein that has recently appeared in the news because a defective variant has been associated with an increased risk of severe influenza, with particular significance within the Chinese population.

Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Transcription regulator involved in inner cell mass and ES cell proliferation and self-renewal.

The Monocyte chemoattractant protein-1 (MCP1) is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes.

Vimentin, a member of the intermediate filament (IF) family, is a protein responsible for maintaining cellular integrity and reducing damage caused by stress.

Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and has been known to play its role in cell growth and proliferation. mTOR is activated by phosphorylationin response to growth factors, mitogens and hormones. Rapamycin is a macrolide antibiotic from Streptomyces hygroscopicus that specifically inhibit the activity of mTOR.