VEGFR2

The cluster of differentiation 4 (CD4) protein is a surface, type I membrane-embedded glycoprotein that is found on a wide range of cells: T-lymphocytes, B-cells, macrophages, granulocytes, and developmentally-dependent regions specific to the brain. It interacts with major histocompatibility complex (MHC) class II anti-genes, serves as the human immunodeficiency virus (HIV) receptor, and can initiate/augment early phase T-cell activation.  In immune-mediated and central nervous system (CNS) infectious diseases, CD4 indirectly mediates neuronal damage.

Vascular endothelial growth factor receptors 1 and 2 (VEGFR1 and VEGFR2) are related family members of the vascular endothelial growth factor (VEGF) family of membrane receptor tyrosine kinases. They are key regulators of physiological angiogenesis during fundamental developmental processes such as embryogenesis, skeletal growth, and reproductive functions.