Antibody catalog

Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and has been known to play its role in cell growth and proliferation. mTOR is activated by phosphorylationin response to growth factors, mitogens and hormones. Rapamycin is a macrolide antibiotic from Streptomyces hygroscopicus that specifically inhibit the activity of mTOR.

As the hormone ghrelin is linked to appetite and weight gain, as well as impaired glucose-induced insulin secretion, there is considerable interest in this peptide as a potential drug target. Although the overall lack of success in this field has been disappointing, research inhibiting the ghrelin-modifying enzyme GOAT (MBOAT4) has produced promising results.

Glial fibrillary acidic protein (GFAP) is a class III intermediate filament (IF) protein and is used as a marker to distinguish astrocytes from other glial cells during development.

Bromodeoxyuridine (BrdU) variously abbreviated as BrdU, BudR, and BrdUrd, is a synthetic thymidine analog that gets incorporated into the DNA of dividing cells during the S-phase of the cell cycle and has a long history of heavy use in molecular and cytokinetic studies (1).

The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development, stem cell self-renewal and regeneration. Alterations in this signaling cascade have been implicated in the pathogenesis of cancer.

HA95 is a nuclear protein with high homology to the nuclear A-kinase anchoring protein AKAP95, involved in the regulation of nuclear envelope-chromatin interactions. Antibody immunostaining data indicate that HA95 is tightly associated with chromatin and the nuclear matrix/lamina network in interphase, and bound to chromatin at mitosis.

Hypoxia-inducible factor-1 is a major transcription factor composed of two subunits: HIF-1alpha and HIF-1 beta. Under normoxic conditions, HIF-1 alpha is targeted to proteosomal degradation via ubiquitination.

Synaptonemal Complex Protein 1 (SCP1) is a novel tumor antigen that belongs to the growing family of cancer/testis antigens (CTA). SCP-1 is known to be selectively expressed during the meiotic prophase of spermatocytes and is involved in the pairing of homologous chromosomes during meiosis I. Investigation of a broad spectrum of normal and malignant tissues revealed that expression of SCP-1 transcripts and antigen selectively in a variety of neoplastic tissues and tumor cell lines.

ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1).

The luciferase reporter is a valuable tool for research into physiology and disease. Light emitted from luciferase enables the monitoring of xenografted tumors, specific cell types, gene expression and pathogens within live animals over time using bioluminescence imaging (BLI) technology. Further detail can be revealed through the use of luciferase antibodies.