ABCG2: A Tumor Protector

Thu, 01/31/2013 - 10:35

ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1). The ABC transporters participate in diverse cellular processes, including drug resistance and metabolism, transport of lipids and organic anions, and iron metabolism, while ABCG1, ABCG4, ABCG5, and ABCG8 are involved in the ATP-dependent translocation of steroids and, possibly, other lipids. ABCG2 is expressed exclusively in the plasma membrane and has been identified to confer resistance to anthracycline anticancer drugs, and is expressed in both malignant and normal tissues (2).

IHC analysis of ABCG2 in human placenta decidual cells IHC analysis of ABCG2 in human placenta decidual cells

In humans, genetic defects of ABC transporters have been implicated in several diseases involving transport deficiencies. Dysfunctions of these proteins have been causally related to several pathological phenotypes, spanning from neurological or metabolic diseases to drug resistance (3). Further investigations on the role of ABCG proteins may facilitate future breakthroughs in the treatment of several transporters related diseases, yet the efforts towards bridging the gap towards clinical applications is an open area of research.

  1. PMID: 22509477
  2. PMID: 16402910
  3. PMID: 14530494

Novus Biologicals offers ABCG2 reagents for your research needs including:

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