Membrane Transport

Connexin 43 and Permeability through Gap Junctions

Gap junctions consist of Connexins (Cx), a family of proteins that form channels linking the cytoplasm of adjacent cells. All Connexin molecules have four membrane-spanning domains, two extracellular domains, and a cytoplasmic carboxy-terminal tail of varying length that has an important role in the regulation of the gating properties of the channel. Interestingly Connexin 43 also known as gap junction alpha-1 protein is one of the most abundant gap-junction protein.

ABCG2: A Tumor Protector

ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1).

Cancer studies with ABCF2

ATP-binding cassette superfamily F2 (ABCF2) is a member of the ATP-binding cassette (ABC) transporter superfamily, and more specifically, a member of the GCN20 subfamily. Most members of this family are membrane proteins that transport various substrates across the cell membrane [1, 2].