HA95/AKAP8L Products

Description

AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease.

Bioinformatics

Product By Gene ID	26993
Alternate Names	A kinase (PRKA) anchor protein 8-like AKAP8-like protein HA95 HAP95 DKFZp434L0650 helicase A-binding protein 95 kDa Homologous to AKAP95 protein HRIHFB2018 NAKAP NAKAP95 A-kinase anchor protein 8-like neighbor of A kinase anchoring protein 95 Neighbor of AKAP95 Neighbor of A-kinase-anchoring protein 95

Research Areas for HA95/AKAP8L

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research
DNA Repair
DNA replication, Transcription, Translation and Splicing
Neuroscience

Related HA95/AKAP8L Blog Posts

Check out the latest blog posts on HA95/AKAP8L.

HA95: Regulator of Nuclear Envelope Dynamics HA95 is a nuclear protein with high homology to the nuclear A-kinase anchoring protein AKAP95, involved in the regulation of nuclear envelope-chromatin interactions. Antibody immunostaining data indicate that HA95 is tightly associated with chromatin ...    Read more.

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