Aldo-keto Reductase 1B10/AKR1B10 Antibody

AKR1B10 (aldo-keto reductase 1B10) is a monomeric enzyme that reduces aliphatic and aromatic aldehydes as well as certain hexoses thereby playing a critical role in detoxification of dietary/cellular alpha or beta-unsaturated carbonyls and lipid peroxides (LPOs) ultimately leading to host cells protection against carbonyl lesions. AKR1B10 is active against polycyclic aromatic hydrocarbon (PAHs) which are potent procarcinogens and against all-trans-retinal, the signaling molecule retinoic acid's precursor which regulates cellular proliferation and differentiation. AKR1B10 is a cytosolic protein, but gets secreted through lysosome-mediated mechanisms and in normal tissues, it is expressed in colon, small intestine, adrenal gland etc., whereas its expression gets upregulated in lung bronchial epithelium of cigarette smokers further augmenting the risk of PAHs mediated initiation of carcinogenesis. Moreover, AKR1B10 is overexpressed in certain cancers such as liver, breast and lung cancer, and because of its reducing potential for C13 ketonic groups of daunorubicin and idarubicin, it may provide chemoresistance for cancer cells to these drugs. Moreover, upregulated AKR1B10 in malignant cells blocks ubiquitin-dependent degradation of ACCA (acetyl-CoA carboxylase-alpha) thereby promoting fatty acid/lipid synthesis which is essential to cancer cell growth and proliferation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-44998	Applications	Species
Chen D, Huang R, Ren F et al. FNDC5 and AKR1B10 inhibit the proliferation and metastasis of adrenocortical carcinoma cells by regulating AMPK/mTOR pathway Experimental and therapeutic medicine 2023-03-01 [PMID: 36845952]
Starmann J, Falth M, Spindelbock W et al. Gene Expression Profiling Unravels Cancer-Related Hepatic Molecular Signatures in Steatohepatitis but Not in Steatosis PLoS One 2012-01-01 [PMID: 23071592] (IF/IHC, Human)	IF/IHC	Human
Wang C, Yan R, Luo D, Watabe K, Liao DF, Cao D. Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. J Biol Chem;284(39):26742-8. 2009-09-25 [PMID: 19643728] (WB, Human)	WB	Human
Quinn AM, Harvey RG, Penning TM. Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10. Chem Res Toxicol;21(11):2207-15. 2008-11-01 [PMID: 18788756] (WB, Human)	WB	Human
Ma J, Yan R, Zu X, Cheng JM, Rao K, Liao DF, Cao D. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. J Biol Chem;283(6):3418-23. 2008-02-08 [PMID: 18056116] (WB, Human)	WB	Human
Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D. Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Int J Cancer;121(10):2301-6. 2007-11-15 [PMID: 17597105] (WB, Human)	WB	Human

Array NBP1-44998

• Aldo-keto Reductase 1B10/AKR1B10 Antibodies
• Aldo-keto Reductase 1B10/AKR1B10 ELISA Kit
• Aldo-keto Reductase 1B10/AKR1B10 Lysate
• Aldo-keto Reductase 1B10/AKR1B10 Proteins
• Aldo-keto Reductase 1B10/AKR1B10 Proteins and Enzyme