Blooms Syndrome Protein Blm [p Thr99] Antibody

Blooms Syndrome Protein Blm, also called DNA helicase RecQ-like type 2 (RecQ2), plays key role in DNA replication and repair. RecQ2 exhibits Mg2+/ATP-dependent DNA-helicase activity which unwind single- and double-stranded DNA in a 3'-5' direction. RecQ2 implicates in 5'-end resection of DNA during double-strand breaks repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. RecQ2 forms a part of the BRCA1-associated genome surveillance complex (BASC, contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2) and RAD50-MRE11-NBS1 protein complex. RecQ2 also interacts with ubiquitinated FANCD2, SUPV3L1 and RMI1 of RMI complex. RecQ2 is localized in the nucleus and gets phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1. RecQ2 has been linked to the etiology of Bloom syndrome (BLM), an autosomal recessive disorder characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-46851	Applications	Species
Shimura T, Torres MJ, Martin MM, Rao VA, Pommier Y, Katsura M, Miyagawa K, Aladjem MI. Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J Mol Biol;375(4):1152-64. 2008-01-25 [PMID: 18054789] (ICC/IF, Human)	ICC/IF	Human
Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol;25(20):8925-37. 2005-10-01 [PMID: 16199871] (WB, ICC/IF, Human)	WB, ICC/IF	Human

Array NBP1-46851

• Blooms Syndrome Protein Blm Antibodies
• Blooms Syndrome Protein Blm Proteins