ZNF198 Antibody Blocking Peptide

Product Discontinued

ZNF198 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 17 amino acids near the amino terminus of human ZMYM2.

  Source: Synthetic

  (Accession #: CAH71822)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ZMYM2
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-76524.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for ZNF198 Antibody Blocking Peptide

• FIMRAMPSCLL
• Fused in myeloproliferative disorders protein
• MYM
• Rearranged in atypical myeloproliferative disorder protein
• Zinc finger protein 198rearranged in an atypical myeloproliferative disorder
• zinc finger, MYM-type 2
• ZNF198zinc finger MYM-type protein 2

Background

Official Gene Symbol: ZMYM2 Gen Bank Accession Number: NP_932072 Gene ID: 7750 (Human) Gene Map Locus: 13q11-q12 (Human) ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ZMYM2