ZBTB38 Antibody [Alexa Fluor® 647]

• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

ZBTB38 Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human ZBTB38
  Met1-Tyr232
  Accession # Q8NAP3
• Specificity: Detects endogenous human ZBTB38 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

ZBTB38 (Zinc finger and BTB domain-containing protein 38; also CIBZ and Zenon) is an early member of a family of Kaiso-like DNA binding proteins. Although its predicted MW is 134 kDa, it runs anomalously in SDS-PAGE at 175 kDa. ZBTB38 binds to singly methylated CpG (cytosine-phosphate-guanine) motifs. It is considered a transcriptional repressor that either homodimerizes, or heterodimerizes with ZBTB4, and subsequently interacts with either CtBP-1 or -2 to mediate repression. Human ZBTB38 is 1195 amino acids (aa) in length. It contains a BTB domain (aa 33‑100), an RD2 region (aa 158‑341) and ten C2H2-type zinc finger domains (aa 342‑1147). There is one potential alternate start site at Met595. Over aa 1‑232, human ZBTB38 shares 96% aa identity with mouse ZBTB38.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.