Recombinant Mouse Uteroglobin/SCGB1A1 Protein

SDS-Page: Mouse Uteroglobin/SCGB1A1 Protein [NBP2-35187]

• Reactivity: Mu
• Applications: PAGE, Bioactivity
• Format: Carrier-Free
• Concentration: LYOPH

Recombinant Mouse Uteroglobin/SCGB1A1 Protein Summary

• Description: A disulfide-linked homodimeric protein containing two 75 amino acid polypeptide chains corresponding to Uteroglobin/SCGB1A1 Source: E. coli

  Uniprot ID: Q06318

  Amino Acid Sequence: DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF

• Details of Functionality: Uteroglobin/SCGB1A1 protein is fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 ug/ml, corresponding to a specific activity of > 200 IU/mg.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: SCGB1A1
• Purity: > 98 % pure by SDS-PAGE and HPLC
• Endotoxin Note: Less than 0.1 EU/ug of Uteroglobin/SCGB1A1 as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 16.7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: > 98 % pure by SDS-PAGE and HPLC
• Reconstitution Instructions: Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.

Alternate Names for Recombinant Mouse Uteroglobin/SCGB1A1 Protein

• Blastokinin
• CC10
• CC10Urine protein 1
• CC16
• CCPBP
• CCSP
• CCSPCCPBP
• Clara cell phospholipid-binding protein
• Clara cells 10 kDa secretory protein
• Clara
• PCB-BP
• SCGB1A1
• Secretoglobin family 1A member 1
• secretoglobin, family 1A, member 1 (uteroglobin)
• UGB
• UGBUP-1
• UP1
• Urinary protein 1
• Uteroglobin

Background

Uteroglobin, also known as secretoglobin family 1A member 1 (SCGB1A1), is encoded by thek SCGB1A1 gene. Uteroglobin is the founding protein of the secretoglobin family, whose members are small, secreted, disulfide-bridged dimeric proteins found in mammals only. Uteroglobin is specifically expressed in clara cells in the lungs. It is multifunctional and found in various tissues in various names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, clara cell secretory protein (CCSP), clara cell 16 kD protein (17 in rat/mice), clara Cell-Specific 10 kD protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human clara cell phospholipid-binding protein (hCCPBP), secretoglobin 1A member 1 (SCGB1A1). Its putative functions include immunomodulation, progesterone binding (weak in some animals, especially weak in humans), phospholipase A2 inhibitor etc. Murine uteroglobin shares 54% amino acid sequence identity with human uteroglobin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SCGB1A1