uPAR Antibody (R-4) - BSA Free

Product Discontinued

uPAR Antibody (R-4) - BSA Free Summary

• Immunogen: Native human uPAR
• Epitope: Antibody reacts with an epitope on domain 3.
• Specificity: Antibody is specific for human uPAR. No cross-reactivity is observed with murine uPAR, human uPA, human tPA or human PAI-1 when tested by ELISA and immunoblotting. MON R-4 reacts with domain 3 when tested by immunoprecipitation of proteolytic fragments of recombinant suPAR.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PLAUR
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Antibody can be used as detection antibody in ELISA.
  Antibody is suitable for Western blotting of non-reduced proteins. This antibody is CyTOF ready.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 10mM Phosphate (pH 7.4) and 0.14M NaCl
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for uPAR Antibody (R-4) - BSA Free

• CD87 antigen
• CD87
• Monocyte activation antigen Mo3
• plasminogen activator, urokinase receptor
• PLAUR
• uPAR
• U-PAR
• UPARurokinase plasminogen activator surface receptor
• u-plasminogen activator receptor form 2
• URKRMO3

Background

uPAR (Urokinase plasminogen activator receptor) is a glycoprotein I anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum beta globulin plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for uPAR Antibody (NBP2-41379)(1)

Publication using NBP2-41379

• Zhu K, Mukherjee K, Wei C et al. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease Science translational medicine 2023-09-20 [PMID: 37729431]

Bioinformatics

• Gene Symbol: PLAUR