Sandwich ELISA: UNC5H2/UNC5B Antibody (1A9) [H00219699-M01] - Detection limit for recombinant GST tagged UNC5B is approximately 1ng/ml as a capture antibody.
UNC5B (NP_734465, 27 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDY
Localization
Membrane; Single-pass type I membrane protein.
Specificity
UNC5B - unc-5 homolog B (C. elegans)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
UNC5B
Purity
IgG purified
Innovator's Reward
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for UNC5H2/UNC5B Antibody (1A9)
p53RDL1
p53-regulated receptor for death and life protein 1
Protein unc-5 homolog 2
Protein unc-5 homolog B
transmembrane receptor Unc5H2
unc5 (C.elegans homolog) b
unc-5 homolog 2
unc-5 homolog B (C. elegans)
UNC5B
UNC5H2
UNC5H2netrin receptor UNC5B
Background
UNC5B belongs to a family of netrin 1 receptors thought to mediate the chemorepulsive effect of netrin 1 on specific axons. Unc5B is required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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