UGT1A9 Antibody (UGT1A9/1229)

Product Discontinued

UGT1A9 Antibody (UGT1A9/1229) Summary

• Immunogen: A synthetic peptide specific to human UGT1A9 protein.
• Localization: Cytoplasmic (Microsome, Endoplasmic reticulum membrane)
• Marker: Hepatocyte & Hepatocellular Carcinoma Marker
• Specificity: It recognizes a protein of about 60kDa, which is identified as human UGT1A9. It does not cross-react with the other UGT1A isoforms including UGT1A7, UGT1A8, and UGT1A10 and shows a high degree of specificity. UGT1A9 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This MAb binds to human hepatocytes and the majority of human hepatocellular carcinomas (HCC s). In frozen sections, it stains hepatic cells and may be used as a marker of the liver. This MAb also binds to cell preparations of hepatocellular carcinoma biopsies or cell lines.
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: UGT1A9
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml
  • Immunofluorescence 0.5 - 1.0 ug/ml
• Application Notes: Hu-chromosome location: 2q37
  Molecular weight of antigen: ~60kDa

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10mM PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein A or G purified

Alternate Names for UGT1A9 Antibody (UGT1A9/1229)

• A12
• EC 2.4.1.17
• GNT1
• HLUGP4
• LUGP4
• polypeptide A9
• UDP glucuronosyltransferase 1 family, polypeptide A9
• UDP-glucuronosyltransferase 1-9
• UDP-glucuronosyltransferase 1A9
• UDP-glucuronosyltransferase 1-I
• UDPGT 1-9
• UDPGT
• UDPGT1-9
• UGT1
• UGT1*9
• UGT1.9
• UGT1-09
• UGT1-9
• UGT1A9
• UGT1AI
• UGT1I
• UGT-1I

Background

UGT1A9 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UGT1A9