TRPM8 Antibody (EPR4196(2))

Product Discontinued

TRPM8 Antibody (EPR4196(2)) Summary

• Immunogen: A synthetic peptide corresponding to residues in the extracellular domain in human TRPM8 was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TRPM8
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:250-500
  • Western Blot 1:1000-10000
• Theoretical MW: 128 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for TRPM8 Antibody (EPR4196(2))

• CMR1
• Long transient receptor potential channel 6
• LTRPC6
• LTrpC-6
• MGC2849
• short form of the TRPM8 cationic channel
• transient receptor potential cation channel, subfamily M, member 8
• Transient receptor potential p8
• transient receptor potential subfamily M member 8
• TRPM8
• TRPP8
• trp-p8
• TRPP8transient receptor potential cation channel subfamily M member 8

Background

TRPM8, or Transient receptor potential cation channel subfamily M member 8, is a receptor-activated non-selective cation channel involved in the detection of sensations such as coolness, by being activated by cold temperatures below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Activated upon depolarization, changes in temperature result in graded shifts of voltage-dependent activation curves for TRPM8. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. TRPM8 is expressed in the prostate, and it is also expressed in most prostate tumors (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRPM8
• Entrez:
  • 79054(Human)
  • 171382(Mouse)
• Uniprot:
  • Q7Z2W7(Human)