TRIM38 Antibody (933011) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 933011
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

TRIM38 Antibody (933011) [Alexa Fluor® 700] Summary

• Immunogen: E.coli-derived recombinant human TRIM38
  Leu190-Ile414
  Accession # O00635
• Specificity: Detects human TRIM38 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TRIM38 Antibody (933011) [Alexa Fluor® 700]

• MGC8946
• RING finger protein 15RORETRo/SSA ribonucleoprotein homolog
• RNF15
• RoRet
• TRIM38
• tripartite motif containing 38
• tripartite motif-containing 38
• tripartite motif-containing protein 38
• Zinc finger protein RoRet
• zinc-finger protein RoRet

Background

Human Tripartite Motif 38 (TRIM38, RNF15) is a 465 aminoacids E3 ubiquitin ligase that plays a key role in tuning TLR-mediated immune responses by selectively targeting molecules in the TLR signaling for proteasomal degradation. The TRIM family of E3 ligases has more than 70 members in humans. Many members of this protein family are important immune regulators, mediating innate immune cell signal transduction and subsequent cytokine induction immune regulation. Trim38 deficiency, for example, greatly increases TLR3- and TLR4-mediated induction of type I Interferons and proinflammatory cytokines, such as TNF-alpha , IL-1 beta , and IL-6, in immune cells and in vivo.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.