Western Blot: TRAIL R1/TNFRSF10A Antibody (32A1380) [NB100-56747] - Analysis of DR4 in Daudi cell lysate using DR4 antibody at 2 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were ...read more
Simple Western: TRAIL R1/TNFRSF10A Antibody (32A1380) [NB100-56747] - Simple Western lane view shows a specific band for TRAIL R1 in 0.5 mg/ml of Daudi lysate. This experiment was performed under reducing conditions ...read more
A 57 kDa band should be observed. This antibody is routinely tested be western blot analysis. For other applications, please refer to appropriate published references for more information. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 26044191). Use in Flow-cell surface reported in scientific literature (PMID: 18004565). Use in Flow-intracellular reported in scientific literature (PMID: 17541421).
In Simple Western only 10 - 15 ul of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue. This antibody is CyTOF ready.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
Protein G purified
Alternate Names for TRAILR1/TNFRSF10A Antibody (32A1380)
cytotoxic TRAIL receptor
Death receptor 4
DR4 TRAIL receptor 1
TNF-related apoptosis inducing ligand receptor 1
TNF-related apoptosis-inducing ligand receptor 1
tumor necrosis factor receptor superfamily member 10A
tumor necrosis factor receptor superfamily, member 10a
Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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