Trace Amine Receptor 1 Antibody

Western Blot: Trace Amine Receptor 1 Antibody [NBP2-24714] - Analysis of human TAAR1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysate using NBP2-24714 at 2 ug/ml.

Immunohistochemistry-Paraffin: Trace Amine Receptor 1 Antibody [NBP2-24714] - Analysis of TAAR1 in paraffin-embedded formalin-fixed mouse brain tissue using a rabbit isotype control (top) and (bottom) at 5 ug/ml.

Product Discontinued

Trace Amine Receptor 1 Antibody Summary

• Immunogen: A portion of amino acids 200-230 of human TAAR1 was used as the immunogen
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TAAR1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1-3 ug/ml

Reactivity Notes

Canine (86%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for Trace Amine Receptor 1 Antibody

• MGC126874
• MGC138399
• TA1RP11-295F4.9
• TAAR1
• TAR1
• TaR-1
• TAR1trace amine-associated receptor 1
• trace amine associated receptor 1
• Trace Amine Receptor 1
• Trace amine receptor 1taR-1
• TRAR1

Background

TA1 (Trace amine receptor 1) is a member of the G protein coupled receptor family (subfamily trace amine). It is activated by endogenous trace amines as well as metabolites of the biogenic amine neurotransmitters. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. This receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. TA1 has been reported in human brain, dorsal root ganglion, olfactory bulb, kidney, liver, lung, pancreas, prostate, skeletal muscle, small intestine, spleen, spinal cord, and stomach. An EST for TA1 has been identified from a human stomach cancer library.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Trace Amine Receptor 1 Antibody (NBP2-24714)(2)

Publications using NBP2-24714

• Imbriglio T, Alborghetti M, Bruno V et al. Up-regulation of the Trace Amine Receptor, TAAR-1, in the Prefrontal Cortex of Individuals Affected by Schizophrenia Schizophrenia bulletin 2023-10-28 [PMID: 37897399]
• Carla B, Roxana G, Luisa D et al. Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice Neuropharmacology 2021-07-01 [PMID: 34217776]

Bioinformatics

• Gene Symbol: TAAR1
• Uniprot:
  • Q96RJ0(Human)