Tmp21/p23 Antibody

Product Discontinued

Tmp21/p23 Antibody Summary

• Immunogen: Peptide with sequence C-YLRRFFKAKKLIE corresponding to C-Terminus according to NP_006818.3.
• Epitope: YLRRFFKAKKLIE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TMED10
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Peptide ELISA Detection limit 1:1000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Tmp21/p23 Antibody

• 21 kDa transmembrane-trafficking protein
• p23
• P24(DELTA)
• p24delta
• S31I125
• S31III125
• TMED10
• Tmp21
• TMP21Tmp-21-I
• transmembrane emp24 domain-containing protein 10
• transmembrane emp24-like trafficking protein 10 (yeast)
• Transmembrane protein Tmp21,21 kDa transmembrane trafficking protein

Background

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Tmp21/p23 Antibody (NB100-58962)(1)

Publication using NB100-58962

• Chen F, Hasegawa H, Schmitt-Ulms G et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 2006-04-27 [PMID: 16641999]

Bioinformatics

• Gene Symbol: TMED10
• Entrez:
  • 10972(Human)
  • 68581(Mouse)
  • 84599(Rat)
• Uniprot:
  • NP_006818.3(Human)