TMEM34 Antibody - BSA Free

Western Blot: TMEM34 Antibody [NBP1-77144] - Analysis of TMEM184C in mouse heart tissue lysate with TMEM184C antibody at 1 ug/mL.

Immunocytochemistry/Immunofluorescence: TMEM34 Antibody [NBP1-77144] - Immunofluorescence of TMEM184C in mouse heart tissue with TMEM184B antibody at 20 ug/mL.

Immunohistochemistry-Paraffin: TMEM34 Antibody [NBP1-77144] - Mouse heart tissue with TMEM184C antibody at 5 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TMEM34 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM184C. The immunogen is located within amino acids 340 - 390 of TMEM184C. Amino Acid Squence: VRGHPRKKLFPEDQD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TMEM184C
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1 ug/ml
• Control Peptide:

  TMEM34 Peptide (NBP1-77144PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (87%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TMEM34 Antibody - BSA Free

• TMEM34
• transmembrane protein 184C
• Transmembrane protein 34FLJ10846

Background

Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TMEM184C
• Uniprot:
  • NP_060711(Human)