TIP120A Antibody

Immunohistochemistry-Paraffin: TIP120A Antibody [NBP1-03165] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.

Product Discontinued

TIP120A Antibody Summary

• Immunogen: Synthetic peptide from human TIP120A corresponding to aa 11-24, coupled to KLH.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CAND1
• Purity: Delipidation and Defibrination

Applications/Dilutions

• Dilutions:
  • ELISA 1:2000-1:10000
  • Immunohistochemistry 1:500
  • Immunohistochemistry-Paraffin 1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Serum
• Preservative: 0.01% Sodium Azide
• Purity: Delipidation and Defibrination

Alternate Names for TIP120A Antibody

• cullin-associated and neddylation-dissociated 1
• Cullin-associated and neddylation-dissociated protein 1
• cullin-associated NEDD8-dissociated protein 1
• DKFZp434M1414
• FLJ90441
• KIAA0829FLJ10114
• p120 CAND1
• TBP interacting protein
• TBP-interacting protein 120A
• TBP-interacting protein of 120 kDa A
• TIP120AFLJ38691
• TIP120FLJ10929

Background

CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CAND1
• Entrez:
  • 55832(Human)
  • 71902(Mouse)
  • 117152(Rat)
• Uniprot:
  • Q86VP6(Human)