Thyroglobulin Antibody (TGB04 + TGB05) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clone
TGB04 + TGB05
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

Thyroglobulin Antibody (TGB04 + TGB05) [Janelia Fluor® 646] Summary

Immunogen
Human thyroid follicular cells
Localization
Cytoplasmic and secreted
Marker
Thyroidal Cell Marker
Specificity
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
TG
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thyroglobulin Antibody (TGB04 + TGB05) [Janelia Fluor® 646]

  • AITD3
  • AITD3TGN
  • cog
  • TDH3
  • Tg
  • TGN
  • Thyroglobulin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Thyroglobulin Antibody (NBP2-34724JF646) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-34724AF350
Alexa Fluor 405 NBP2-34724AF405
Alexa Fluor 488 NBP2-34724AF488
Alexa Fluor 532 NBP2-34724AF532
Alexa Fluor 594 NBP2-34724AF594
Alexa Fluor 647 NBP2-34724AF647
Alexa Fluor 700 NBP2-34724AF700
Alexa Fluor 750 NBP2-34724AF750
Allophycocyanin NBP2-34724APC
Biotin NBP2-34724B
DyLight 350 NBP2-34724UV
DyLight 405 NBP2-34724V
DyLight 488 NBP2-34724G
DyLight 550 NBP2-34724R
DyLight 594 NBP2-34724DL594
DyLight 650 NBP2-34724C
DyLight 680 NBP2-34724FR
DyLight 755 NBP2-34724IR
FITC NBP2-34724F
HRP NBP2-34724H
Janelia Fluor 549 NBP2-34724JF549
Janelia Fluor 646 NBP2-34724JF646
PE NBP2-34724PE

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Bioinformatics Tool for Thyroglobulin Antibody (NBP2-34724JF646)

Discover related pathways, diseases and genes to Thyroglobulin Antibody (NBP2-34724JF646). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on Thyroglobulin.

TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Bioinformatics

Gene Symbol TG