Thyroglobulin Antibody (2H11+6E1)

Images

 
Immunohistochemistry-Paraffin: Thyroglobulin Antibody (2H11+6E1) [NBP2-34294] - Thyroglobulin staining in thyroid tissue of normal C57 mouse (Red). Dilution is 1:100. This image was submitted via customer Review.
Immunohistochemistry-Paraffin: Thyroglobulin Antibody (2H11+6E1) [NBP2-34294] - Analysis using Azide/BSA FREE version of NBP2-34294. Human Thyroid stained with Thyroglobulin Ab (2H11 + 6E1).
Immunohistochemistry: Thyroglobulin Antibody (2H11+6E1) [NBP2-34294] - Imaging of Mouse stomach tissue. Positive staining can only be observed inside the thyroid cells and the follicle in thyroid tissue. This image was ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clone
2H11+6E1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Thyroglobulin Antibody (2H11+6E1) Summary

Immunogen
Human thyroid follicular cells
Localization
Cytoplasmic and secreted
Marker
Thyroidal Cell Marker
Specificity
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
TG
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-1.0ug/ml
  • Flow Cytometry 0.5-1.0ug/million cells
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100
Application Notes
Human Chromosome Location: 8q24.22
Mol. Weight of Antigen: 660kDa (Dimeric Form)
Immunohistochemistry (formalin-fixed) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Theoretical MW
660 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 1 Review rated 5
using
NBP2-34294 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
PBS with 0.05% BSA.
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for Thyroglobulin Antibody (2H11+6E1)

  • AITD3
  • AITD3TGN
  • cog
  • TDH3
  • Tg
  • TGN
  • Thyroglobulin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Thyroglobulin Antibody (NBP2-34294) (0)

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Review for Thyroglobulin Antibody (NBP2-34294) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NBP2-34294:
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IHC
(1)
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Mouse
(1)
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Images Ratings Applications Species Date Details
Immunohistochemistry Thyroglobulin NBP2-34294
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reviewed by:
Feng Li
IHC Mouse 06/20/2017
View

Summary

ApplicationImmunohistochemistry
Sample TestedStomach tissue
SpeciesMouse
Lot7038-3P160707

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Blogs on Thyroglobulin.

TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Recent Reviews

5
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2
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1
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Feng Li
06/20/2017
Application: IHC
Species: Mouse

Bioinformatics

Gene Symbol TG
Entrez
Uniprot