Specific activity is > 15 units/mg, and was measured in a coupled assay with 5,5 -Dithiobis(2-nitrobenzoic acid) (DTNB) and NADPH. The amount of TNB generated by NADPH was measured in absorbance at 412 nm.
>95% pure by SDS-PAGE
55.7 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using NBP1-44456 in the following applications:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4), 10% glycerol
>95% pure by SDS-PAGE
Alternate Names for Recombinant Human Thioredoxin Reductase 1/TRXR1 Protein
Gene associated with retinoic and IFN-induced mortality 12 protein
Gene associated with retinoic and interferon-induced mortality 12 protein
KM-102-derived reductase-like factor
Thioredoxin Reductase 1
thioredoxin reductase 1, cytoplasmic
thioredoxin reductase GRIM-12
Thioredoxin reductase TR1
TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases. Recombinant human TXNRD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
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FAQs for Thioredoxin Reductase 1/TRXR1 Recombinant Protein (NBP1-44456). (Showing 1 - 1 of 1 FAQ).
Does this protein contain selenocystein?
According to the lab, the selenocysteine was cleaved for this protein. The domain of our recombinant human thioredoxin reductase 1 is 161-647aa. which corresponds to the TGR domain (161-649aa) minus the selenocysteine.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.