Testican 2/SPOCK2 Antibody (327403)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
327403
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

Testican 2/SPOCK2 Antibody (327403) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Testican 2/SPOCK2
Glu23-Trp424
Accession # Q92563
Specificity
Detects human Testican 2/SPOCK2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Testican 1 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SPOCK2
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunoprecipitation 25 ug/mL
Publications
Read Publication using
MAB2328 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Testican 2/SPOCK2 Antibody (327403)

  • FLJ97039
  • KIAA0275
  • KIAA0275CWCV, and Kazal-like domains proteoglycan 2
  • sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
  • SPOCK2
  • Testican 2

Background

Testican 2 encoded by the SPOCK2 gene is a proteoglycan highly expressed in brain (1, 2). The human and mouse cDNAs predict 94% identity between the deduced amino acid sequences from the two species, indicating a conserved function (3, 4). Testican 2 contains a Ca2+-binding domain and a C-terminal acidic domain with putative glycosaminoglycan attachment sites. In addition, it contains three potential inhibitory domains targeted toward three different classes of proteases, metallo, cysteine and serine proteases. However, these domains may not be involved directly in the inhibition of targeted proteases. For example, Testican 2 is not able to inhibit MMP-14 (MT1-MMP, a metalloprotease) activation of MMP-2 (5). Nonetheless, overexpression of Testican 2 is able to abrogate inhibition of MMP-14 by other testican family members and to inhibit neurite outgrowth (6, 7).

  1. Nagase, T. et al. (1996) DNA Res. 3:321.
  2. Vannahme, C. et al. (1999) J. Neurochem. 73:12.
  3. Strausberg, R.L. et al. (2002) Proc. Natl. Acad. Sci. USA 99:16899.
  4. Okazaki, Y. et al. (2002) Nature 420:563.
  5. Nakada, M. et al. (2001) Cancer Res. 61:8896.
  6. Nakada, M. et al. (2003) Cancer Res. 63:3364.
  7. Hartmann, U. and P. Maurer (2001) Matrix Biol. 20:23.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Testican 2/SPOCK2 Antibody (MAB2328)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.


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(1)
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Bioinformatics

Gene Symbol SPOCK2
Uniprot