TEP1 Antibody

Western Blot: TEP1 Antibody [NBP1-03224] - Western blot of TEP1 in human kidney tissue lysate with TEP1 antibody at (A) 1 and (B) 2 ug/ml.

Immunohistochemistry-Paraffin: TEP1 Antibody [NBP1-03224] - Staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunohistochemistry-Paraffin: TEP1 Antibody [NBP1-03224] - Staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence: TEP1 Antibody [NBP1-03224] - Immunofluorescence of TEP1 in Human Lung cells with TEP1 antibody at 20 ug/ml.

Product Discontinued

TEP1 Antibody Summary

• Immunogen: A 20 aa synthetic peptide near the N-terminus of human TEP1. The immunogen is located within the first 50 aa of TEP1.
• Epitope: N-Terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TEP1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TEP1 Antibody

• p240telomerase protein component 1
• telomerase-associated protein 1VAULT2
• TLP1p80 telomerase homolog
• TP1Telomerase protein 1
• TROVE domain family, member 1
• TROVE1

Background

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TEP1
• Entrez:
  • 7011(Human)
  • 21745(Mouse)
  • 64523(Rat)
• Uniprot:
  • Q99973(Human)