TAS1R3 Antibody

• Reactivity: Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: LYOPH

TAS1R3 Antibody Summary

• Immunogen: A synthetic peptide from mouse TAS1R3 conjugated to blue carrier protein was used as the antigen.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TAS1R3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500
  • Immunohistochemistry-Paraffin 1:500
  • Western Blot 1:500
• Application Notes: A dilution of 1 :500 is recommended as a starting point. The optimal dilution should be determined by the end user.
• Control:

  TAS1R3 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Alternate Names for TAS1R3 Antibody

• T1R3Sweet taste receptor T1R3
• taste receptor type 1 member 3
• taste receptor, type 1, member 3
• TR3

Background

FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.; SUBUNIT: Forms homodimers or heterodimers with TAS1R1 and TAS1R2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in circumvallate, foliate and fungiform taste papillae as well as in taste buds on the palate. Also expressed in testis. Not expressed in brain, heart, kidney, liver or spleen. The topographic distribution in various taste papillae is different from those of other T1R members.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TAS1R3 Antibody (NB100-98792)(1)

Publication using NB100-98792

• Smith K, Karimian-Azari E, LaMoia T et al. T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways Molecular Metabolism 2018-08-01 [PMID: 30201274] (WB, Mouse)

Bioinformatics

• Gene Symbol: TAS1R3
• Entrez:
  • 83771(Mouse)
  • 170634(Rat)
• Uniprot:
  • Q925D8(Mouse)