Syntaxin-BP3/Munc18c Antibody [Alexa Fluor™ Plus 405]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 405

Syntaxin-BP3/Munc18c Antibody [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human Syntaxin‑BP3 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) STXBP1 and rhSTXBP2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Syntaxin-BP3/Munc18c Antibody [Alexa Fluor™ Plus 405]

• MUNC18-3
• Munc18c
• Platelet Sec1 protein
• Protein unc-18 homolog 3
• Protein unc-18 homolog C
• PSP
• STXBP3
• syntaxin 4 binding protein
• syntaxin binding protein 3
• syntaxin-binding protein 3
• SyntaxinBP3
• Syntaxin-BP3
• unc18-3
• Unc-18C

Background

Syntaxin‑BP3 (Syntaxin-binding protein 3; also PSP, Munc18-C and -3; and Unc-18C) is a 66‑70 kDa member of the SNARE-interacting Sec1/Munc18 family of proteins. It is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. Functionally, it likely participates in the consolidation and secretion of secondary and tertiary granules. Human Syntaxin‑BP3 is 592 amino acids (aa) in length. It contains one SEC1 domain (aa 16‑592). Phosphorylation at Ser129 may stimulate granule release. There are two potential splice variants. One shows a 12 aa substitution for aa 31‑269, while a second shows a one aa Gln insertion after Lys270. Over aa 84‑231, human Syntaxin‑BP3 shares 90% aa identity with mouse Syntaxin‑BP3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.