Syntaxin 1A Antibody

Product Discontinued

Syntaxin 1A Antibody Summary

• Immunogen: Peptide with sequence KDRTQELRTAKD-C corresponding to N-Terminus according to NP_001159375.1, NP_443106.1.
• Specificity: Please note this product is expected to recognize the products of 2 different genes. STX1A (NP_004594.1and NP_001159375.1) and STX1B (NP_443106.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: STX1A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 0.01 - 0.03 ug/ml
• Application Notes: WB: Approx. 35 kDa band observed in mouse brain lysates (calculated MW of 33.0 kDa band according to NP_004594.1 and 33.2 kDa band according to NP_443106.1).
• Control:

  Mouse Brain Whole Tissue Lysate (Adult Whole Normal)

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human, Rat, Canine, Bovine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Syntaxin 1A Antibody

• Brain Syntaxin
• HPC-1
• Neuron-specific antigen HPC-1
• p35-1
• STX1A
• STX1P35-1
• SYN1A
• syntaxin 1A (brain)
• Syntaxin 1A
• syntaxin-1A

Background

Please note this product is expected to recognize the products of 2 different genes. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Syntaxin 1A Antibody (NB600-818)(1)

Publication using NB600-818

• Kang Y, Leung YM, Manning-Fox JE et al. Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. J Biol Chem 2004-11-05 [PMID: 15339904]

Bioinformatics

• Gene Symbol: STX1A
• Entrez:
  • 6804(Human)
  • 20907(Mouse)
  • 116470(Rat)
• Uniprot:
  • NP_004594.1(Human)