Striatin Antibody

Images

 
Western Blot: Striatin Antibody [NB110-74571] - Immunoblot of PP2A immunoprecipitate with NB110-74571.
Immunocytochemistry/ Immunofluorescence: Striatin Antibody [NB110-74571] - Immunofluorescent staining of NIH3T3 cells ± blocking peptide using NB110-74571.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Striatin Antibody Summary

Immunogen
Synthetic peptide made to an internal portion of the human Striatin protein (within residues 350-400). [Swiss-Prot# O43815]
Localization
Cell Membrane and Cytoplasmic
Specificity
This antibody specific for Striatin. It does not cross-react with SG2NA.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
STRN
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:5000
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:500-1:5000
Application Notes
This Striatin antibody is useful in Western blot, Immunocytochemistry/Immunofluorescence and Immunoprecipitation. In WB a band can be seen at ~110 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Striatin Overexpression Lysate
Publications
Read Publications using
NB110-74571 in the following applications:

  • 2 publications
  • IP
    3 publications
  • WB
    1 publication

Reactivity Notes

Human, mouse and rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.02% Sodium Azide
Purity
Unpurified

Alternate Names for Striatin Antibody

  • MGC125642
  • SG2NA
  • striatin
  • striatin, calmodulin binding protein
  • striatin, calmodulin-binding protein

Background

Striatin (STRN) is a calmodulin-binding member of WD-repeat family of proteins/WD repeat striatin family and is an intracellular protein localized mainly in cytoplasm as well as in cellular membranes as peripheral membrane protein, and is mostly present in neurons of mammalian basal ganglia and cranial/spinal motor nuclei. Striatin's protein-protein interaction domains include caveolin-binding (amino acids 55-63), coiled-coil (amino acids 70-116), Ca2+-calmodulin-binding (amino acids 149-166), and a series of eight WD repeat (amino acids 419-780) motifs. Striatin is a scaffolding protein which functions in a calcium dependent fashion and is implicated in cellular signaling and trafficking processes. Striatin forms complex with PP2A (protein phosphatase 2A) which associates directly to and controls the function of ER-alpha. Moreover, striatin targets ER-alpha to the cell membrane and serves as a scaffold for the assembly of proteins essential to rapid, estrogen-induced eNOS activation. Striatin has also been suggested as a candidate gene for human ARVC (arrhythmogenic right ventricular cardiomyopathy), familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Striatin Antibody (NB110-74571)(5)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IP, WB.


Filter By Application
ICC/IF
(2)
IP
(3)
WB
(1)
All Applications
Filter By Species
Human
(2)
Mouse
(1)
Rat
(1)
All Species

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Striatin Antibody (NB110-74571) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol STRN
Entrez
Uniprot