Somatostatin R4/SSTR4 Antibody

Images

 
Western Blot: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of 25 ug of HepG2 (lane 1), Jurkat (lane 2) and NIH-3T3 (lane 3) cell lysates.
Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative ...read more
Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of SH-SY5Y cells (right) compared to a negative ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Somatostatin R4/SSTR4 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues C(366) Q Q E A L Q P E P G R K R I P L T R T T T F(388) of human SSTR4.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SSTR4
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:5000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:2500
  • Immunocytochemistry 1:250
  • Immunofluorescence 1:250
Application Notes
WB: Analysis of SSTR4 transfected HEK-293 cells detects an approx. 40 - 50 kDa protein representing SSTR4.
Publications
Read Publication using
NB100-74539 in the following applications:

  • IHC
    1 publication

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Whole serum
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Somatostatin R4/SSTR4 Antibody

  • G-protein coupled receptor
  • Somatostatin R4
  • somatostatin receptor 4
  • somatostatin receptor type 4
  • SomatostatinR4
  • SS4R
  • SS-4-R
  • SS4-R
  • SSTR4

Background

SSTR4 has been reported to be expressed in brain, gastrointestinal tract, pancreas, and prostate tissues. No ESTs have been identified. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Somatostatin R4/SSTR4 Antibody (NB100-74539)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.


Filter By Application
IHC
(1)
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Filter By Species
Human
(1)
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Bioinformatics

Gene Symbol SSTR4
Entrez
Uniprot