SOCS-2 Antibody (517206) [mFluor Violet 500 SE]

• Reactivity: Hu
• Applications: WB
• Clone: 517206
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 500 SE

SOCS-2 Antibody (517206) [mFluor Violet 500 SE] Summary

• Immunogen: E. coli-derived recombinant human SOCS-2
  Met1-Gln197 (predicted)
  Accession # O14508
• Specificity: Detects human SOCS-2 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: SOCS2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SOCS-2 Antibody (517206) [mFluor Violet 500 SE]

• CIS2
• CIS2CIS-2
• Cish2
• Cytokine-inducible SH2 protein 2
• SOCS2
• SOCS-2
• SOCS-2STAT-induced STAT inhibitor 2
• SSI2
• SSI-2STAT induced STAT inhibitor-2
• SSI2STAT-induced STAT inhibitor-2
• STATI2
• STATI2suppressor of cytokine signaling-2
• suppressor of cytokine signaling 2

Background

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SOCS2