SNW1 Antibody (PCRP-SNW1-1C12) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Applications: Flow
• Clone: PCRP-SNW1-1C12
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

SNW1 Antibody (PCRP-SNW1-1C12) [Alexa Fluor™ Plus 647] Summary

• Immunogen: Recombinant fragment of human SNW1 protein
• Localization: Nucleus, Cytosol
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SNW1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted to react with chicken, mouse and rat.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SNW1 Antibody (PCRP-SNW1-1C12) [Alexa Fluor™ Plus 647]

• Bx42
• homolog of Drosophila BX42
• MGC119379
• NCoA-62
• Nuclear protein SkiP
• Nuclear receptor coactivator NCoA-62
• nuclear receptor coactivator, 62-kD
• Prp45
• PRPF45
• SKI interacting protein
• Ski-interacting protein
• SKIPSKIIP
• SNW domain containing 1
• SNW domain-containing protein 1

Background

SNW1, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SNW1