SmarcAL1 Recombinant Enzymes

• Reactivity: Hu
• Applications: NULL

SmarcAL1 Recombinant Enzymes Summary

• Description: Human HARP (aa 2-953) fused to 6xHis and FLAG-tag at the N-terminus. (Uniprot: Q9NZC9)
• Source: Sf 9 (baculovirus)
• Protein/Peptide Type: Recombinant Enzymes
• Gene: SMARCAL1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • N/A

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 15% glycerol, 2 mM MgCl2, 0.2 mM EDTA, 1 mM DTT, 10 mM beta-glycerophospate, 0.4 mM PMSF, 1 mM benzamidine and 0.4 mg/ml recombinant human insulin
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for SmarcAL1 Recombinant Enzymes

• ATP-driven annealing helicase
• EC 3.6.1
• EC 3.6.4.-
• HARPSWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A-like protein 1
• HepA-related protein
• hHARP
• SIOD
• SMARCA-like protein 1
• subfamily a-like 1
• Sucrose nonfermenting protein 2-like 1
• SWI/SNF related, matrix associated, actin dependent regulator of chromatin

Background

SmarcAL1 is encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SMARCAL1