SLITRK1 Antibody

Product Discontinued

SLITRK1 Antibody Summary

• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Slitrk1. The immunogen is located within amino acids 630 - 680 of Slitrk1.
• Specificity: This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLITRK1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SLITRK1 Antibody

• FLJ54428
• KIAA1910KIAA0918
• leucine rich repeat containing 12
• Leucine-rich repeat-containing protein 12
• LRRC12
• RP11-395N17.1
• SLIT and NTRK-like family, member 1
• SLIT and NTRK-like protein 1
• slit and trk like gene 1
• SLITRK1
• TTM

Background

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLITRK1
• Uniprot:
  • NP_443142()