SLC39A4/ZIP4 Antibody

Product Discontinued

SLC39A4/ZIP4 Antibody Summary

• Immunogen: Peptide with sequence C-RQPKPPHEGSRAD corresponding to internal region according to NP_060237.2, NP_570901.2.
• Epitope: internal region
• Specificity: This antibody is expected to recognize both reported isoforms (NP_060237.2; NP_570901.2)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SLC39A4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments in human colon and Ileum lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SLC39A4/ZIP4 Antibody

• acrodermatitis enteropathica, zinc-deficiency type
• AEZ
• FLJ20327
• MGC74741
• SLC39A4
• solute carrier family 39 (zinc transporter), member 4
• Solute carrier family 39 member 4
• zinc transporter ZIP4
• ZIP4
• ZIP-4
• ZIP4AEZ
• Zrt- and Irt-like protein 4

Background

SLC39A4/ZIP4 is a gene that codes for a protein that plays a role as a zinc transporter in cellular zinc homeostasis and has two isoforms, with lengths of 647 and 622 amino acids and weights of approximately 68 and 66 kDa respectively. Current research is being done on several diseases and disorders related to this gene including enteropathica, autosomal recessive disease, mental disorders, alopecia, diarrhea, dermatitis, pancreatic cancer, pancreatitis, and carcinoma. SLC39A$/ZIP4 has also been shown to be incvolved in pathways such as the senescence and autophagy, metal ion SLC transporters, and mineral absorption pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC39A4/ZIP4 Antibody (NBP1-36988)(1)

Publication using NBP1-36988

• Li M, Zhang Y, Liu Z et al. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A 2007-11-20 [PMID: 18003899]

Bioinformatics

• Gene Symbol: SLC39A4
• Entrez:
  • 55630(Human)
• Uniprot:
  • NP_060237.2(Human)