SLC26A7 Antibody (14H5) [DyLight 405]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF
Clone
14H5
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

SLC26A7 Antibody (14H5) [DyLight 405] Summary

Immunogen
A fusion protein containing the C-terminal region of mouse SLC26A7. [Swiss-Prot# Q24JS8]
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
SLC26A7
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This SLC26A7 antibody is useful for Western blot on cells transiently transfected with mouse SLC26A7 and also for Immunocytochemistry/Immunofluorescence. In WB a band can be seen at ~90-100 kDa representing SLC26A7. Note: Do not boil the samples.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SLC26A7 Antibody (14H5) [DyLight 405]

  • MGC126268
  • solute carrier family 26, member 7
  • sulfate anion transporter

Background

SLC26A7 (solute carrier family 26 member 7) is a chloride-base exchanger and/or chloride transporter that is expressed on basolateral membrane of acid-secreting cells in renal outer medullary collecting duct (OMCD) and in gastric parietal cells also. SLC26A7 belongs to conserved family of anion transporters SLC26 isoforms which display tissue-specific expression patterns in epithelial cells and several SLC26 members function as chloride/bicarbonate exchangers that include SLC26A3 (DRA), SLC26A4 (pendrin), SLC26A6 (PAT1 or CFEX), SLC26A7, and SLC26A9 among which SLC26A7 and SLC26A9 also function as chloride channels. In renal tissues, Slc26a7 co-localizes with AE1, a well-known Cl-/HCO3- exchanger, on the basolateral membrane of (acid-secreting) A-intercalated cells in OMCD cells, and in the gastric tissue, SLC26A7 co-localizes with AE2, a major Cl-/HCO3- exchanger, on the basolateral membrane of acid secreting parietal cells. SLC26A7 acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. SLC26A7 maintains the electrolyte/acid-base homeostasis in kidneys by acting as a distal excretory segment-specific anion exchanger, specifically chloride, and plays a major role in gastric acid secretion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-60965B
DyLight 350 Labeled NB110-60965UV
DyLight 488 Labeled NB110-60965G
DyLight 550 Labeled NB110-60965R
DyLight 650 Labeled NB110-60965C
DyLight 680 Labeled NB110-60965FR
DyLight 755 Labeled NB110-60965IR
FITC Labeled NB110-60965F
HRP Labeled NB110-60965H

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Bioinformatics Tool for SLC26A7 Antibody (NB110-60965V)

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Bioinformatics

Gene Symbol SLC26A7