SIRP beta 1/gamma Antibody (308906) [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready
• Clone: 308906
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 610 SE

SIRP beta 1/gamma Antibody (308906) [mFluor Violet 610 SE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human SIRP beta 1
  Gly26-Ala369 (Arg53His and Ala363Pro)
  Accession # O00241.4
• Specificity: Detects human SIRP beta 1 and human SIRP gamma in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SIRPB1

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SIRP beta 1/gamma Antibody (308906) [mFluor Violet 610 SE]

• CD172 antigen-like family member B
• CD172b
• signal-regulatory protein beta-1
• SIRP beta 1/gamma
• SIRP-BETA-1

Background

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SIRPB1