SIRP beta 1/gamma Antibody (308906) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready
• Clone: 308906
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

SIRP beta 1/gamma Antibody (308906) [Janelia Fluor® 669] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human SIRP beta 1
  Gly26-Ala369 (Arg53His and Ala363Pro)
  Accession # O00241.4
• Specificity: Detects human SIRP beta 1 and human SIRP gamma in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SIRPB1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SIRP beta 1/gamma Antibody (308906) [Janelia Fluor® 669]

• CD172 antigen-like family member B
• CD172b
• signal-regulatory protein beta-1
• SIRP beta 1/gamma
• SIRP-BETA-1

Background

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SIRPB1