SHP-1 Antibody

Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in mouse spleen.

Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in HeLa.

Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in human pancreas.

Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in mouse lung.

Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in transfected 293T cell line by PTPN6 polyclonal antibody.Lane 1: PTPN6 transfected lysate(67.60 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

SHP-1 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: PTPN6 (NP_002822.2, 1 a.a. - 595 a.a.) full-length human protein. MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPN6
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: It has been used for WB.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for SHP-1 Antibody

• HCP
• HCPH
• HPTP1C
• PTP1C
• PTP-1C
• PTPN6
• SHP1
• SHP-1
• SHP-1L
• SH-PTP1

Background

SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPN6
• Uniprot:
  • NP_002822.2(Human)